4-Toluenesulfonyl chloride → HCID 86585315, compound

Participants

Reaction Steps

320 mg of tosyl chloride and 70 mg of dimethylamino-pyridine are added to 690 mg of the product obtained in Stage D in 5 cm3 of pyridine, then two lots of 115 mg of tosyl chloride is added again. Agitation is carried out for 2 hours and 30 minutes, followed by acidifying with 6N hydrochloric acid, extraction with ethyl acetate, washing with an aqueous solution of sodium bicarbonate, with salt water, drying and evaporating the solvent under reduced pressure, the residue is chromatographed on silica (eluant: ethyl acetate-essence G 7-3 then ethyl acetate). 710 mg of expected product is obtained.

Provenance & Evidence