Formic Acid → HCID 18179277, compound

Participants

Reaction Steps

To 50 ml of toluene were added 23 g (56 mmol) of 4-(3,5-difluoro-4-iodophenyl)cyclohexanecarboaldehyde propylene ketal obtained above and 39 g (848 mmol) of formic acid, and the mixture was refluxed for 2 hours. The reaction solution was washed with water, further with a saturated aqueous sodium bicarbonate and then with water and dried over magnesium sulfate. The solvent was distilled off to afford 19 g (54 mmol) of 4-(3,5-difluoro-4-iodophenyl)cyclohexanecarboaldehyde.

Provenance & Evidence