Trifluoroacetic acid → HCID 86585656, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (7R)-7-[2-(2-amino-5-chloro-thiazol-4-yl)-2-trityloxyiminoacetylamino ]-3-(5-amino-[1,3,4]thiadiazol-2-ylsulfanyl)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester (150 mg, 0.17 mmol) in dichloromethane (7.5 mL) was added triethylsilane (1.5 mL). The mixture was cooled to 0° C. and trifluoroacetic acid (7.5 mL) was added. After 2 hr at 0° C. the reaction mixture was concentrated under vacuum and disopropyl ether was added to the oily residue. The title compound precipitated and was filtered, washed with additional diisopropyl ether and dried under vacuum (85 mg, 65%).

Provenance & Evidence