Trifluoroacetic acid → HCID 86585660, compound

Participants

Reaction Steps

To a solution of (7R)-7-[2-[5-chloro-2-(tritylamino)-thiazol-4-yl]-2-(2-fluoro-ethoxyimino)-acetylamino]-3-(5-amino-[1,3,4]thiadiazol-2-ylsulfanyl)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid t-butyl ester (8 mg, 0.009 mmol) in dichloromethane (0.16 mL) was added triethylsilane (0.04 mL), followed by trifluoroacetic acid (0.16 mL). After 3 hr at room temperature the reaction mixture was concentrated under vacuum and disopropyl ether was added to the oily residue. The title compound precipitated and was filtered, washed with additional diisopropyl ether and dried under vacuum (3 mg, 32%).

Provenance & Evidence