化工社化工社 化学情報印刷レポート · 研究参考用
tert-Butyl 4-(2-methoxy-5-nitrophenyl)piperazine-1-carboxylate → Tert-butyl 4-(5-amino-2-methoxyphenyl)piperazine-1-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | tert-Butyl 4-(2-methoxy-5-nitrophenyl)piperazine-1-carboxylate | HCID 18180062 | — |
| 反応物 | HCID 178418361 | HCID 178418361 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Tert-butyl 4-(5-amino-2-methoxyphenyl)piperazine-1-carboxylate | HCID 10686178 | 99% |
反応手順
A slurry of 10% palladium on carbon (10 g) in a solution of 4-tert-butoxycarbonyl-1-(2-methoxy-5-nitrophenyl)piperazine (D2) (124.5 g) in ethanol (3.5L) and water (50 ml) was stirred with hydrogen at ambient temperature and atmospheric pressure for 18 h. The reaction mixture was filtered and the filtrate concentrated to afford the title compound (D3) as a gum (112 g, 99%). MH+ 308.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06599904B2 |
| 出典データセット | uspto-grants-2003_07 |
| ORD ID | ord-6b3e017198c046ea952784515861017e |
| 出典メモ | uspto-grants-2003_07 |