HCID 18180081, compound → HCID 18180106, compound

Participants

Reaction Steps

A solution of stannous chloride dihydrate (27 g) in concentrated HCl (60 ml) was slowly added to a stirred suspension of 1-(2-methoxy-5-nitrophenyl)-4-trichloroacetylpiperazine (D15) (15 g) in concentrated HCl/ethanol (1:2, 120 ml). After 24 hrs, the mixture was filtered, diluted with dichloromethane (600 ml) and basified with Na2CO3 solution. The layers were separated, the organic phase dried, concentrated to ⅓ the volume and acidified with 1M ethereal HCl solution to afford the title compound (D16) as a green solid (2.5 g, 15%). Found MH+ 352.

Provenance & Evidence