HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Chloro-3-methylbenzo(b)thiophene-2-sulfonyl chloride → 5-Chloro-3-methylbenzo[b]thiophene-2-sulfonic acid[4-chloro-3-(4-methylpiperazin-1-yl)phenyl]amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Chloro-3-methylbenzo(b)thiophene-2-sulfonyl chloride | HCID 2735756 | — |
| Reactant | 4-Chloro-3-(4-methylpiperazin-1-yl)aniline | HCID 18180073 | — |
| Product | 5-Chloro-3-methylbenzo[b]thiophene-2-sulfonic acid[4-chloro-3-(4-methylpiperazin-1-yl)phenyl]amide | HCID 18180047 | — |
Reaction Steps
The title compound (E119) was prepared from 4-chloro-3-(4-methylpiperazin-1-yl)benzenamine (EP 0533267A, intermediate 42) (50 mg, 0.22 mmol) and 5-chloro-3-methylbenzo[b]thiophene-2-sulfonyl chloride (62 mg, 0.22 mmol) using the method of Example 1 (49 mg, 44%) MH+=470/472.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06599904B2 |
| Source dataset | uspto-grants-2003_07 |
| ORD ID | ord-afc940f137814533b5d530f9c1c2704b |
| Source note | uspto-grants-2003_07 |