5-Chloro-3-methylbenzo(b)thiophene-2-sulfonyl chloride → HCID 18180087, compound

HRID 1358956Notes

Reaction equation

HRID 1358956 reaction equation
[CH3:1][N:2]([CH3:15])[CH2:3][CH2:4][N:5]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([NH2:14])[CH:12]=2)[CH2:7][CH2:6]1.[Cl:16][C:17]1[CH:30]=[CH:29][C:20]2[S:21][C:22]([S:25](Cl)(=[O:27])=[O:26])=[C:23]([CH3:24])[C:19]=2[CH:18]=1>>[CH3:1][N:2]([CH3:15])[CH2:3][CH2:4][N:5]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([NH:14][S:25]([C:22]3[S:21][C:20]4[CH:29]=[CH:30][C:17]([Cl:16])=[CH:18][C:19]=4[C:23]=3[CH3:24])(=[O:27])=[O:26])[CH:12]=2)[CH2:7][CH2:6]1

Participants

3

Reactant 2

HCID 27357565-Chloro-3-methylbenzo(b)thiophene-2-sulfonyl chlorideHCID 21939769HCID 21939769, compound

Product 1

HCID 18180087HCID 18180087, compound

Procedure

The title compound (E122) was prepared from 1-(2-dimethylaminoethyl)-2,3-dihydro-1H-indol-6-ylamine (WO95/32967 Description 4) (100 mg, 0.49 mmol) and 5-chloro-3-methylbenzo[b]thiophene-2-sulfonyl chloride (137 mg, 0.49 mmol) using the method of Example 1 (40 g, 18%) MH+=450/452.

Sources & evidence

ORD record
ord-f08ec3dcea96471898a6d7b3799154a5
Source dataset
uspto-grants-2003_07
Patent number
US06599904B2

Reaction notes

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