5-Chloro-3-methylbenzo(b)thiophene-2-sulfonyl chloride → HCID 18180083, compound

HRID 1358958Notes

Reaction equation

HRID 1358958 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][C:11]=1[N:12]1[CH2:17][CH2:16][N:15]([CH3:18])[CH2:14][CH2:13]1)[NH:8][CH2:7][CH2:6]2.[Cl:19][C:20]1[CH:33]=[CH:32][C:23]2[S:24][C:25]([S:28](Cl)(=[O:30])=[O:29])=[C:26]([CH3:27])[C:22]=2[CH:21]=1>>[Cl:19][C:20]1[CH:33]=[CH:32][C:23]2[S:24][C:25]([S:28]([N:8]3[C:9]4[C:5](=[CH:4][C:3]([O:2][CH3:1])=[C:11]([N:12]5[CH2:13][CH2:14][N:15]([CH3:18])[CH2:16][CH2:17]5)[CH:10]=4)[CH2:6][CH2:7]3)(=[O:29])=[O:30])=[C:26]([CH3:27])[C:22]=2[CH:21]=1

Participants

3

Reactant 2

HCID 27357565-Chloro-3-methylbenzo(b)thiophene-2-sulfonyl chlorideHCID 18180053HCID 18180053, compound2×

Product 1

HCID 18180083HCID 18180083, compound

Procedure

The title compound (E124) was prepared from 5-methoxy-6-(4-methylpiperazin-1-yl)-2,3-dihydro-1H-indole (WO95/06637 intermediate 3) (99 mg, 0.4 mmol) and 5-chloro-3-methylbenzo[b]thiophene-2-sulfonyl chloride (113 mg, 0.4 mmol) using the method of Example 1 (194 mg, 92%) MH+=492/494.

Sources & evidence

ORD record
ord-970f5a6d958d4a1bbef1959cf880f4d2
Source dataset
uspto-grants-2003_07
Patent number
US06599904B2

Reaction notes

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