Acetic Anhydride → HCID 18180200, compound

HRID 1358970Notes

Reaction equation

HRID 1358970 reaction equation
[NH2:1][C:2]1[C:7]([Br:8])=[N:6][CH:5]=[C:4]([NH2:9])[N:3]=1.[C:10](OC(=O)C)(=[O:12])[CH3:11]>COC(OC)C>[NH2:1][C:2]1[C:7]([Br:8])=[N:6][CH:5]=[C:4]([NH:9][C:10](=[O:12])[CH3:11])[N:3]=1

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 18180211HCID 18180211, compound

Product 1

HCID 18180200HCID 18180200, compound

Reagents, catalysts & solvents 1

HCID 107951,1-DimethoxyethaneSolvent

Procedure

A mixture of 2,6-diamino-3-bromopyrazine (10.509, 0.056 mole) in dry 1,1-dimethoxyethane (168 ml) and acetic anhydride (7.91 ml, 8.56 g, 0.084 mole) was refluxed under nitrogen for 2.50 hrs. The cooled mixture was evaporated in vacuo. The residue was triturated with ether, filtered and dried in vacuo Yield 10.31 g (80%), M.p. 218-221° C.

Workup

  1. temperaturewas refluxed under nitrogen for 2.50 hrs
  2. customThe cooled mixture was evaporated in vacuo
  3. customThe residue was triturated with ether
  4. filtrationfiltered
  5. customdried in vacuo Yield 10.31 g (80%), M.p. 218-221° C.

Sources & evidence

ORD record
ord-9d224b91d28b498e86c65bdbe264a534
Source dataset
uspto-grants-2003_07
Patent number
US06599905B2

Reaction notes

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