反应详情

温度

55 °C

Stannous chloride (0.182 g, 0.0096 mole) was added to the suspension of 2-isopropylcarbonylamino-6-acetamido-3-(2,3,5-trichlorophenyl)pyrazine (0.13 g, 3.24×10−4 mole), in absolute ethanol (6.50 ml) and the resulting mixture stirred at 50-60° C. for 1 hr 20 min. The reaction mixture was cooled and evaporated in vacuo. The residue was extracted with ethylacetate (3×20 ml), washed with water (2×20 ml), dried over anhydrous magnesium sulphate, filtered and the filtrate evaporated in vacuo. The residue was purified by ‘flash chromatography’ using chloroform:methanol, 99:1 as the eluent. Yield 0.046 g (40%), M.p. 105-108° C.

1. temperatureThe reaction mixture was cooled
2. customevaporated in vacuo
3. extractionThe residue was extracted with ethylacetate (3×20 ml)
4. washwashed with water (2×20 ml)
5. dry with materialdried over anhydrous magnesium sulphate
6. filtrationfiltered
7. customthe filtrate evaporated in vacuo
8. customThe residue was purified by ‘flash chromatography’