3,5-bis-(1,1-dimethylethyl)-4-hydroxy-N-[(4-nitrophenyl)methyl]-benzamide → 4-acetoxy-3,5-dimethoxy-N-[(4-aminophenyl)methyl]-benzamide

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Reaction Steps

The experimental protocol used is the same as that described for intermediate 2.2, 4-acetoxy-3, 5-dimethoxy-N-[(4-nitrophenyl)methyl]-benzamide replacing the 3,5-bis-(1,1-dimethylethyl)-4-hydroxy-N-[(4-nitrophenyl)methyl]-benzamide. A colourless oil is obtained with a yield of 82%. The product is used directly in the following stage without additional purification.

Provenance & Evidence