HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4-Nitrophenyl)acetic acid → Benzeneacetyl chloride, 4-nitro-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4-Nitrophenyl)acetic acid | HCID 4661 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Benzeneacetyl chloride, 4-nitro- | HCID 6452210 | — |
Reaction Steps
3.75 ml (7.5 mmoles) of a 2M solution of oxalyl chloride in dichloromethane is added at 20° C. to a solution of 0.9 g (5 mmoles) of 4-nitrophenylacetic acid in a mixture composed of 10 ml of dichloromethane and 0.5 ml of DMF. After agitation for 30 minutes, the solution is concentrated under vacuum. The yellow oil obtained is used without additional purification in the following stage.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06599903B2 |
| Source dataset | uspto-grants-2003_07 |
| ORD ID | ord-22ec307b8534421582a27e9b2ef713df |
| Source note | uspto-grants-2003_07 |