Water → HCID 9879865, compound

Participants

Reaction Steps

1-benzoyl-5-amino-1H-indole (25 mg, 0.106 mmol) was dissolved in dichloromethane (1.0 ml) at room temperature and mesyl chloride (0.01 ml. 0.116 mmol) and triethylamine (0.016 ml, 0.115 mmol) were added. The solution was stirred at room temperature for 30 minutes to complete the reducing reaction. After pouring water (2 ml), dichloromethane layer was separated, washed with brine, dried over anhydrous magnesium sulfate and then, purified through flash column chromatography (an eluent:ethyl acetate/n-hexane=1/2, v/v). As a result, the present compound (20 mg, productive yield 60%) was obtained.

Provenance & Evidence