反应详情

Under the presence of nitrogen, 5-nitroindolin (50 mg, 0.30 mmol) was dissolved in dimethylformamide (2 ml) at room temperature and benzyl bromide (0.04 ml. 0.34 mmol) and potassium carbonate (0.126 ml, 3.0 equivalent) were added and stirred at room temperature for 48 hours. After completing the reaction, water and ethyl acetate (respectively 5 ml) were added to separate layers, washed with brine, dried over anhydrous magnesium sulfate, and concentrated. Finally, the residue was purified through flash column chromatography (an eluent:ethyl acetate/n-hexane=1/4, v/v). As a result, the present compound (45 mg, productive yield 58%) was obtained.

1. additionwere added
2. customto separate layers
3. washwashed with brine
4. dry with materialdried over anhydrous magnesium sulfate
5. concentrationconcentrated
6. customFinally, the residue was purified through flash column chromatography (an eluent
7. customAs a result, the present compound (45 mg, productive yield 58%) was obtained