Sodium Bicarbonate → HCID 9869745, compound

Participants

Reaction Conditions

Reaction Steps

The compound from Step A (0.587 g, 1.2 mmol) was dissolved in glacial acetic acid (7.0 ml) and concentrated H2SO4 (1 drop) was added. The mixture was heated for 20 min at 75° C. with stirring. The reaction was neutralized with NaHCO3 (10.5 g in 25 ml of water) and extracted with methyl t-butyl ether (3×25 ml), evaporated and dried under high vacuum. The residue was chromatographed on silica gel with acetone/hexane (1:2) to give 0.407 g (85%) of the title compound. 1H-NMR (400 MHz, CDCl3) δH 0.77 (3H, d, CH3), 0.83 (3H, d, CH3), 1.47 (3H, s, CH3), 1.55 (2H, m, NCH2CH2CH2), 1.76 (4H, m, NCH2CH2CH2), 2.72 (4H, br, NCH2CH2CH2), 2.95 (2H, t, OCH2CH2N), 3.11 (3H, s, CH3), 4.24 (2H, t, OCH2CH2N), 6.87-8.78 (10H, ArH).

Provenance & Evidence