反应详情

While heating under reflux a 28% sodium methoxide methanol solution mildly, a mixture of 135 g of 4-benzoyl-2-chloropyridine and 150 ml of methanol was added dropwise thereinto over one hour, followed by heating under reflux for further 2 hours. After cooling as it was, the reaction solution was filtered to remove insoluble matters and the solvent was removed. To the residue was added an aqueous sodium bicarbonate solution and the mixture was extracted with ethyl acetate. The organic phase was washed with brine, dried over anhydrous magnesium sulfate and then the solvent was removed, to give 130 g of the target compound.

1. temperatureWhile heating
2. additionwas added dropwise
3. temperatureby heating
4. temperatureunder reflux for further 2 hours
5. temperatureAfter cooling as it
6. filtrationthe reaction solution was filtered
7. customto remove insoluble matters
8. customthe solvent was removed
9. additionTo the residue was added an aqueous sodium bicarbonate solution
10. extractionthe mixture was extracted with ethyl acetate
11. washThe organic phase was washed with brine
12. dry with materialdried over anhydrous magnesium sulfate
13. customthe solvent was removed