反应详情

A mixture of 104 g of 4-(α-hydroxybenzyl)-2-methoxypyridine, 100 ml of acetic acid anhydride and 100 ml of pyridine was heated under stirring for 5 hours in an oil bath kept at 110° C. After the reaction solution was evaporated, water was added to the residue and the mixture was extracted with ethyl acetate. The extract was washed with an aqueous sodium bicarbonate solution and brine, dried over anhydrous magnesium sulfate and the solvent was removed. The residue was subjected to silica gel column chromatography using 5-20% ethyl acetate/hexane, to give 112 g of the target compound.

1. temperaturewas heated
2. customkept at 110° C
3. customAfter the reaction solution was evaporated
4. additionwater was added to the residue
5. extractionthe mixture was extracted with ethyl acetate
6. washThe extract was washed with an aqueous sodium bicarbonate solution and brine
7. dry with materialdried over anhydrous magnesium sulfate
8. customthe solvent was removed