HCID 18182367, compound → HCID 18182278, compound

HRID 1359273Notes

Reaction equation

HRID 1359273 reaction equation
[CH2:1]([O:8][C:9]1[C:10]([CH:16]([OH:23])[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[N:11][C:12]([CH3:15])=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[C:16]([C:10]1[C:9]([O:8][CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[CH:14][CH:13]=[C:12]([CH3:15])[N:11]=1)(=[O:23])[C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

Participants

4

Reactant 1

HCID 18182367HCID 18182367, compound

Product 1

HCID 18182278HCID 18182278, compoundYield 98.1%

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6212ChloroformSolvent

Procedure

116 g of 3-benzyloxy-2-(α-hydroxybenzyl)-6-methylpyridine was dissolved in 500 ml of chloroform. 400 g of manganese dioxide was added under stirring, followed by heating under stirring at 60 ° C. for one hour in an oil bath. After cooling as it was, the reaction solution was filtered to remove insoluble matters, and the solvent was removed. The resulting crystals were vacuum-dried, to give 113 g of the target compound.

Workup

  1. temperatureby heating
  2. stirringunder stirring at 60 ° C. for one hour in an oil bath
  3. temperatureAfter cooling as it
  4. filtrationthe reaction solution was filtered
  5. customto remove insoluble matters
  6. customthe solvent was removed
  7. customThe resulting crystals were vacuum-dried

Sources & evidence

ORD record
ord-a0786d63418a466d9207085507de8198
Source dataset
uspto-grants-2003_07
Patent number
US06599917B1

Reaction notes

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