2-(Tributylstannyl)pyridine → HCID 18182276, compound

Participants

Reaction Steps

A mixture of 150 mg of 3-(3-benzyl-5-bromo-2-pyridyl)ethynyl-3-quinuclidinol, 150 mg of (2-pyridyl)tributyltin, 86 mg of tetrakis(triphenylphosphine)palladium(0) and 3.5 ml of toluene was heated under stirring in an oil bath kept at 110° C. for 2 hours in a nitrogen atmosphere. After cooling as it was, NH-silica gel was added to the reaction solution and the solvent was removed. The residue was subjected to NH-silica gel column chromatography using 2.5% methanol/ethyl acetate, to give 100 mg of the target compound.

Provenance & Evidence