Methanol → HCID 18182209, compound

HRID 1359306Notes

Reaction equation

HRID 1359306 reaction equation
Cl[C:2]1[C:7]([C:8]([C:10]2[S:11][CH:12]=[CH:13][CH:14]=2)=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[CH3:15][OH:16].C[O-].[Na+]>O>[CH3:15][O:16][C:2]1[C:7]([C:8]([C:10]2[S:11][CH:12]=[CH:13][CH:14]=2)=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1

Participants

5

Reactant 3

HCID 887Methanol2×HCID 10942334Sodium MethoxideHCID 15135620(2-Chloropyridin-3-yl)(thiophen-2-yl)methanone

Product 1

HCID 18182209HCID 18182209, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 1.64 g of 2-chloro-3-(2-thienylcarbonyl)pyridine, 4.5 ml of a methanol solution of 28% sodium methoxide and 2.0 ml of methanol was heated under stirring for 30 minutes. After cooling as it was, water was added to the reaction solution and the mixture was extracted with ethyl acetate. The organic phase was washed with brine and the solvent was removed, to give 1.46 g of the target compound.

Workup

  1. temperaturewas heated
  2. temperatureAfter cooling as it
  3. extractionthe mixture was extracted with ethyl acetate
  4. washThe organic phase was washed with brine
  5. customthe solvent was removed

Sources & evidence

ORD record
ord-af2b9092f05f4d2892503c49254bcc4f
Source dataset
uspto-grants-2003_07
Patent number
US06599917B1

Reaction notes

Loading…