Tetrahydropyran-2-methanol → HCID 18182313, compound

Participants

Reaction Conditions

Reaction Steps

Sodium hydride was added to a mixture of 456 mg of 2-benzyl-6-iodo-3-(methoxymethyloxy)pyridine, 122 mg of cuprous iodide and 3 ml of tetrahydropyran-2-methanol, followed by stirring at 90° C. for 3 hours. An aqueous ammonium chloride solution and ethyl acetate were added to the reaction solution, followed by stirring at room temperature for one hour. Then, the organic phase was washed with water and brine, dried over anhydrous magnesium sulfate and the solvent was removed. The residue was subjected to silica gel column chromatography using 15% ethyl acetate/hexane, to give 383 mg of the target compound.

Provenance & Evidence