1,2-Dichloroethane → HCID 18182189, compound

Participants

Reaction Steps

201 mg of sodium cyanotrihydroborate was added to a mixture of 85.7 mg of 3-ethynyl-2-(α-hydroxybenzyl)thiophene, 192 mg of zinc iodide and 1.5 ml of 1,2-dichloroethane at room temperature, followed by stirring at the same temperature overnight. 5 ml of diethyl ether was added to the reaction solution, followed by filtering through Celite. After the solvent was removed, the residue was subjected to silica gel column chromatography using 2% ethyl acetate/hexane, to give 45.2 mg of the target compound.

Provenance & Evidence