反应详情

温度

100 °C

A mixture of 3.3 g of 2-amino−4-bromobenzaldehyde, 3.3 g of 1-methoxy-3-phenylacetone, an aqueous potassium hydroxide solution (10 g of potassium hydroxide was dissolved in 10 ml of water) and 20 ml of ethanol was heated under stirring at 100° C. for 4 hours in a sealed tube. After cooling as it was, the reaction solution was poured into water and the mixture was extracted with diethyl ether. The organic phase was washed with brine and the solvent was removed. The residue was crystallized from hexane/ethyl acetate, to give 3.7 g of the target compound.

1. temperatureAfter cooling as it
2. extractionthe mixture was extracted with diethyl ether
3. washThe organic phase was washed with brine
4. customthe solvent was removed
5. customThe residue was crystallized from hexane/ethyl acetate