反应详情

5.0 g of benzyl chloromethyl ketone (Example 211a) was dissolved in 20 ml of ethanol and 2.3 g of thiourea was added thereto, followed by heating under reflux for 3 hours. After cooling as it was, the solvent was removed and the residue was subjected to NH-silica gel column chromatography using 50% ethyl acetate/hexane and ethyl acetate as an eluent for separation and purification, to give 1.7 g of the target compound.

1. temperatureby heating
2. temperatureunder reflux for 3 hours
3. temperatureAfter cooling as it
4. customthe solvent was removed
5. customfor separation and purification