Imidazole → HCID 10618349, compound

Participants

Reaction Steps

The hydroxyethyl pyrrolopyrimidine (1.4) (1.91 g, 7.8 mmol) was dissolved in DMF (25 ml) and tert-butyldimethylsilyl chloride (1.77 g, 11.7 mmol) and imidazole (1.6 g, 23.5 mmol) added and the solution stirred at room temperature for 6 hours. The solvent was removed and the product dissolved in chloroform, washed with water and the solvent evaporated. The product was precipitated by trituration with methanol, filtered and dried to give an off-white solid. A second fraction was obtained by concentration of the mother liquors. Yield 2.51 g, 89%. δH −0.07 (6H, s, 2×CH3), 0.80 (9H, s, C(CH3)3), 2.52 (3H, s, SCH3), 2.94 (2H, t, J 7.0 Hz, OCH2CH2), 3.78 (2H, t, J 7.0 Hz, OCH2), 7.29 (1H, s, H6), 12.10 (1H, s, NH) ppm.

Provenance & Evidence