4-Aminophenethyl alcohol → HCID 9908990, compound

HRID 1359452Notes

Reaction equation

HRID 1359452 reaction equation
C(OC([NH:8][C:9]([C:12]1[CH:17]=[CH:16][C:15]([C:18]2[C:23]([Cl:24])=[CH:22][N:21]=[C:20](Cl)[N:19]=2)=[CH:14][C:13]=1[F:26])([CH3:11])[CH3:10])=O)(C)(C)C.[NH2:27][C:28]1[CH:36]=[CH:35][C:31]([CH2:32][CH2:33][OH:34])=[CH:30][CH:29]=1>>[NH2:8][C:9]([C:12]1[CH:17]=[CH:16][C:15]([C:18]2[C:23]([Cl:24])=[CH:22][N:21]=[C:20]([NH:27][C:28]3[CH:36]=[CH:35][C:31]([CH2:32][CH2:33][OH:34])=[CH:30][CH:29]=3)[N:19]=2)=[CH:14][C:13]=1[F:26])([CH3:10])[CH3:11]

Participants

3

Reactant 2

HCID 669044-Aminophenethyl alcoholHCID 18183242HCID 18183242, compound

Product 1

HCID 9908990HCID 9908990, compound

Procedure

The title compound was prepared from 4-[4-(1-tert-butoxycarbonylamino-1-methylethyl)-3-fluorophenyl]-2,5-dichloropyrimidine (1.60 g, 4.0 mmol) and 4-aminophenethyl alcohol (826 mg, 6.0 mmol) following the method of Example 1.

Sources & evidence

ORD record
ord-e39c6396e7f74e2f88af25388dd202a6
Source dataset
uspto-grants-2003_07
Patent number
US06600037B1

Reaction notes

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