反应详情

温度

84 °C

A mixture of 6.20 g of commercial 2,4,6-triamino-5-nitrosopyrimidine, 5.15 g of 2,4-diamino-6-hydroxypyrimidine and 3.92 g of sulfamic acid in 230 ml of water is finely stirred for one minute by means of an ULTRA-TURRAX® stirring rod and heated to a temperature in the range of from 82 to 86° C. The mixture is stirred at that temperature for 17 hours and then filtered over a laminated paper filter while still hot. The residue is washed with hot water until the pH of the washing water is above 4. After drying in vacuo at 110 ° C., there are obtained 10.28 g (75% of the theoretical yield) of a light-yellow powder of the pyrimido-[5,4-g]pteridine salt of formula IV, the acid being sulfamic acid.

1. stirringstirring rod
2. stirringThe mixture is stirred at that temperature for 17 hours
3. filtrationfiltered over a laminated paper
4. filtrationfilter while still hot
5. washThe residue is washed with hot water until the pH of the washing water
6. customAfter drying in vacuo at 110 ° C.
7. customthere are obtained 10.28 g (75% of the