関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Sodium Cyanide | HCID 8929 | — |
| 反応物 | 1-(Chloromethyl)-4-(methylthio)benzene | HCID 70128 | — |
| 触媒 | Tetrabutylammonium Chloride | HCID 70681 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 2-(4-(Methylthio)phenyl)acetonitrile | HCID 2760087 | 100.5% |
反応手順
Under an atmosphere of nitrogen, 25.9 g (150 mmol) of 4-(methylthio)benzyl chloride were dissolved in 45.5 g of toluene. 9.29 g (180 mmol) of sodium cyanide, 0.92 g (2.9 mmol) of tetrabutylammonium chloride and 14.4 g of water were then added. The mixture was stirred at 80-85° C. for 2 h. The reaction mixture was admixed with 30 g of toluene and 45 g of water, the aqueous phase was decanted off and the organic phase was concentrated. This gave a residue of 24.6 g of the title product in a yield of >95% (according to NMR) in the form of a pink solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US06600046B2 |
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| 出典データセット | uspto-grants-2003_07 |
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| ORD ID | ord-5d20e59d26884dacb8738d998af5841b |
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| 出典メモ | uspto-grants-2003_07 |
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