Phosphonic acid, (2-chloroethyl)-, diethyl ester → Tetraethyl ethylenebisphosphonate

HRID 1359539Notes

Reaction equation

HRID 1359539 reaction equation
Cl[CH2:2][CH2:3][P:4](=[O:11])([O:8][CH2:9][CH3:10])[O:5][CH2:6][CH3:7].[PH:12](=[O:19])([O:16][CH2:17][CH3:18])[O:13][CH2:14][CH3:15].[K]>>[CH2:2]([P:12](=[O:19])([O:16][CH2:17][CH3:18])[O:13][CH2:14][CH3:15])[CH2:3][P:4](=[O:11])([O:8][CH2:9][CH3:10])[O:5][CH2:6][CH3:7]

Participants

3

Reactant 2

HCID 25250Phosphonic acid, (2-chloroethyl)-, diethyl esterHCID 178476839HCID 178476839, compound

Product 1

HCID 70446Tetraethyl ethylenebisphosphonate

Procedure

For example, K. Moedritzer, R. R. Irani, J. Inorg. Nucl. Chem. 22 (1961) 297-304 describes by way of example a process which begins by reacting diethyl β-chloroethylphosphonate with potassium diethyl phosphonate to give tetraethyl ethylenediphosponate, which is then converted into the desired ethylenediphosphonic acid by hydrolysis with concentrated hydrochloric acid.

Sources & evidence

ORD record
ord-b5f777007cae447cb2d528cf1774d780
Source dataset
uspto-grants-2003_07
Patent number
US06600067B2

Reaction notes

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