HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-1-butanol → (1r)-1-Bromocyclopropanecarboxylic acid-2-hydroxy-1-ethylethylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-1-butanol | HCID 22129 | — |
| Reactant | 1-Bromocyclopropane-carboxylic acid chloride | HCID 10910206 | — |
| Reactant | (IR)-1-bromocyclopropanecarboxylic acid-2-hydroxy-1-phenylethylamide | HCID 21350875 | — |
| Product | (1r)-1-Bromocyclopropanecarboxylic acid-2-hydroxy-1-ethylethylamide | HCID 21350874 | — |
Reaction Steps
Analogously to the production of amide 110, 2.18 g of acid chloride 107 is reacted with 962 mg of (-)-2-amino-1-butanol, whereby 2.3 g of (1R)-1-bromocyclopropanecarboxylic acid-2-hydroxy-1-ethylethylamide 114 is obtained as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06600058B1 |
| Source dataset | uspto-grants-2003_07 |
| ORD ID | ord-453a460edc2e465594ad31e29f2a055e |
| Source note | uspto-grants-2003_07 |