Acetic Anhydride → HCID 18183126, compound

Participants

Reaction Steps

0.72 g (2.13 mmol) of the aminomethyl compound from step B is dissolved in 6 ml of acetic anhydride at 25° C. and allowed to stand for 1 hour. The solution is diluted with ice water (30 ml) and stirred for 2 hours. The precipitated substance is filtered and, after drying by column chromatography, purified (silica gel, eluant ethyl acetate:benzene=4:1). After the fractions are concentrated by evaporation, 0.65 g of crystalline substance is obtained, which after washing with ethanol yields 0.56 g (70%) of pure title compound with a melting point of 205° C. (decomposition).

Provenance & Evidence