HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pentyl nitrite → HCID 11347663, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pentyl nitrite | HCID 10026 | — |
| Reactant | 5-(4-aminophenyl)-8-methyl-11H-1,3-dioxolo[4,5-h]imidazo[1,2-c][2,3]benzodiazepine | HCID 18183170 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 11347663 | HCID 11347663 | 71.2% |
Reaction Steps
200 mg of 5-(4-aminophenyl)-8-methyl-11H-1,3-dioxolo[4,5-h]imidazo[1,2-c][2,3]benzodiazepine is mixed in 30 ml of tetrahydrofuran with 1.32 ml of pentyl nitrite and refluxed under argon for 2 hours. After concentration by evaporation, it is chromatographed on silica gel with methylene chloride:ethanol=10:1. 136 mg of 8-methyl-5-phenyl-11H-1,3-dioxolo[4,5-h]imidazo[1,2-c][2,3]benzodiazepine is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06600036B2 |
| Source dataset | uspto-grants-2003_07 |
| ORD ID | ord-29325bdc9b2849a687721a06f3df8179 |
| Source note | uspto-grants-2003_07 |