Guanidine → HCID 178464068, compound

Participants

Reaction Steps

1.5 g of CDI are added to a suspension of 2.0 g of 6-(2-diethylaminoethoxy)-1-naphthoic acid in 50 ml of THF, and the reaction mixture is stirred at RT overnight. It is then treated with 2.0 g of guanidine, again stirred overnight and concentrated, and the residue is stirred with 100 ml of water. The precipitate formed is filtered off with suction and purified by FC using methylene chloride/methanol 1:1.0.66 g of 6-(2-diethylaminoethoxy)-1-naphthoylguanidine is obtained; m.p.: 168-169° C. 1H-NMR (DMSO-d6): δ [ppm]=1.0 (6H), 2.6 (4H), 2.85 (2H), 4.15 (2H), 7.15 (1H), 7.3 (1H), 7.4 (1H), 7.75 (2H), 8.7 (1H).

Provenance & Evidence