反应详情

A mixture of 2-hydroxybenzyl alcohol (1.295 g, 10.4 mmol) and 4-(2-chloroethyl)morpholine hydrochloride (1.94 g, 10.4 mmol) in 2N NaOH (10.5 mL) was stirred at rt for 14 hours. The precipitate was collected by vacuum filtration, washed with 1N NaOH, redissolved in DCM and washed with 1N NaOH. The aqueous layer was extracted with more DCM (2×). The combined DCM was dried and concentrated to give [2-(2-morpholin-4-yl-ethoxy)-phenyl]-methanol which was used without further purification.

1. filtrationThe precipitate was collected by vacuum filtration
2. washwashed with 1N NaOH
3. dissolutionredissolved in DCM
4. washwashed with 1N NaOH
5. extractionThe aqueous layer was extracted with more DCM (2×)
6. dry with materialThe combined DCM was dried
7. concentrationconcentrated