5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic Acid → 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-[1,2,3)triazol-1-yl-ethyl)amide

HRID 1359672Notes

Reaction equation

HRID 1359672 reaction equation
[CH:1]([C:3]1[NH:7][C:6]([CH3:8])=[C:5]([C:9]([OH:11])=O)[C:4]=1[CH3:12])=[O:2].[N:13]1([CH2:18][CH2:19][NH2:20])[CH:17]=[CH:16][N:15]=[N:14]1>>[N:13]1([CH2:18][CH2:19][NH:20][C:9]([C:5]2[C:4]([CH3:12])=[C:3]([CH:1]=[O:2])[NH:7][C:6]=2[CH3:8])=[O:11])[CH:17]=[CH:16][N:15]=[N:14]1

Participants

3

Reactant 2

HCID 110737925-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic AcidHCID 225619722-(1H-1,2,3-Triazol-1-yl)ethanamine

Product 1

HCID 207617305-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-[1,2,3)triazol-1-yl-ethyl)amideYield 98%

Procedure

5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2 g, 11.96 mmol) reacted with 2-[1,2,3]triazol-1-yl-ethylamine (2.66 g, 14.36 mmol) to give 3.05 g (98%) of 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-[1,2,3]triazol-1-yl-ethyl)-amide.

Sources & evidence

ORD record
ord-3a08cb279d25446988e2a7f926fe5a6e
Source dataset
uspto-grants-2003_07
Patent number
US06599902B2

Reaction notes

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