HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-2-cyclopropylcarbamoyl-pyrrolidine-1-carboxylic acid benzyl ester → (R)-N-Cyclopropylpyrrolidine-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-2-cyclopropylcarbamoyl-pyrrolidine-1-carboxylic acid benzyl ester | HCID 69995760 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (R)-N-Cyclopropylpyrrolidine-2-carboxamide | HCID 21139077 | 79.1% |
Reaction Steps
(R)-2-Cyclopropylcarbamoyl-pyrrolidine-1-carboxylic acid benzyl ester (2.6 g) was hydrogenated using 5% Pd/C (260 mg) in methanol (25 mL). The filtrate was concentrated to give 1.1 g (79%) of (R)-pyrrolidine-2-carboxylic acid cyclopropylamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06599902B2 |
| Source dataset | uspto-grants-2003_07 |
| ORD ID | ord-16aeb5e646524d08bf250fb2624b4c7b |
| Source note | uspto-grants-2003_07 |