Trifluoroacetic acid → HCID 69997349, compound

Participants

Reaction Steps

Trifluoroacetic acid (5 mL) was added to a solution of (S)-2-((R)-3-fluoro-pyrrolidin-1-ylcarbonyl)-pyrrolidine-1-carboxylic acid tert-butyl ester (700 mg, 2.4 mmol) in dichloromethane (5 mL). After stirring at room temperature for 2 h, the reaction mixture was concentrated. The residue was dissolved in methanol-water (1:1), neutralized to pH>10 with OH− formed resin. After concentration, 400 mg (89%) of ((R)-3-fluoro-pyrrolidin-1-yl)-(S)-pyrrolidin-2-yl-methanone was obtained.

Provenance & Evidence