5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic Acid → HCID 59077619, compound

HRID 1359718Notes

Reaction equation

HRID 1359718 reaction equation
[CH3:1][C:2]1[CH:21]=[CH:20][CH:19]=[C:18]([CH3:22])[C:3]=1[CH2:4][S:5]([C:8]1[CH:9]=[C:10]2[C:14](=[CH:15][CH:16]=1)[NH:13][C:12](=[O:17])[CH2:11]2)(=[O:7])=[O:6].[CH:23]([C:25]1[NH:29][C:28]([CH3:30])=[C:27]([C:31]([OH:33])=[O:32])[C:26]=1[CH3:34])=O>>[CH3:22][C:18]1[CH:19]=[CH:20][CH:21]=[C:2]([CH3:1])[C:3]=1[CH2:4][S:5]([C:8]1[CH:9]=[C:10]2[C:14](=[CH:15][CH:16]=1)[NH:13][C:12](=[O:17])/[C:11]/2=[CH:23]\[C:25]1[NH:29][C:28]([CH3:30])=[C:27]([C:31]([OH:33])=[O:32])[C:26]=1[CH3:34])(=[O:7])=[O:6]

Participants

3

Reactant 2

HCID 110737925-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic AcidHCID 18179798HCID 18179798, compound

Product 1

HCID 59077619HCID 59077619, compound

Procedure

5-[(2,6-Dimethylbenzyl)sulfonyl]-1,3-dihydro-indol-2-one (315 mg, 1 mmol) was condensed with 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (170 mg, 1 mmol) to give the titled compound as an orange-brown solid.

Sources & evidence

ORD record
ord-456c92ae72ea437a9ab8abaff58ef7b7
Source dataset
uspto-grants-2003_07
Patent number
US06599902B2

Reaction notes

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