5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic Acid → HCID 59077715, compound

HRID 1359719Notes

Reaction equation

HRID 1359719 reaction equation
[Cl:1][C:2]1[C:21]([Cl:22])=[CH:20][CH:19]=[CH:18][C:3]=1[CH2:4][S:5]([C:8]1[CH:9]=[C:10]2[C:14](=[CH:15][CH:16]=1)[NH:13][C:12](=[O:17])[CH2:11]2)(=[O:7])=[O:6].[CH:23]([C:25]1[NH:29][C:28]([CH3:30])=[C:27]([C:31]([OH:33])=[O:32])[C:26]=1[CH3:34])=O>>[Cl:1][C:2]1[C:21]([Cl:22])=[CH:20][CH:19]=[CH:18][C:3]=1[CH2:4][S:5]([C:8]1[CH:9]=[C:10]2[C:14](=[CH:15][CH:16]=1)[NH:13][C:12](=[O:17])/[C:11]/2=[CH:23]\[C:25]1[NH:29][C:28]([CH3:30])=[C:27]([C:31]([OH:33])=[O:32])[C:26]=1[CH3:34])(=[O:6])=[O:7]

Participants

3

Reactant 2

HCID 110737925-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic AcidHCID 18179794HCID 18179794, compound

Product 1

HCID 59077715HCID 59077715, compound

Procedure

5-[(2,3-Dichlorobenzyl)sulfonyl]-1,3-dihydro-indol-2-one (315 mg, 1 mmol) was condensed with 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (170 mg, 1 mmol) to give the titled compound as a solid.

Sources & evidence

ORD record
ord-4a579b07ef6e436abade4bdc78a626e2
Source dataset
uspto-grants-2003_07
Patent number
US06599902B2

Reaction notes

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