HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1359723Generated: October 27, 2026
1-Hydroxybenzotriazole → HCID 59077655, compound
https://huagongshe.com/reaction/1359723
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | (R)-3-Pyrrolidinol | HCID 2759337 | — |
| Reactant | 5-[5-(2,6-dichloro-phenylmethanesulfonyl)-2-oxo-1,2-dihydro-indol-(3Z)-ylidenemethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid | HCID 59077507 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 59077655 | HCID 59077655 | — |
Reaction Steps
A mixture of 5-[5-(2,6-dichloro-phenylmethanesulfonyl)-2-oxo-1,2-dihydro-indol-(3Z)-ylidenemethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (100 mg, 0.2 mmol), (R)-pyrrolidin-3-ol (34 mg, 0.2 mmol), HOBt (20 mg), EDAC.HCl (40 mg) and TEA (40 mg, 3 eq.) in DMF was stirred at 40° C. for 3 days. The reaction was concentrated and purified on a silica gel column to give the titled compound. MS m/z 572 [M−1].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06599902B2 |
|---|
| Source dataset | uspto-grants-2003_07 |
|---|
| ORD ID | ord-6bd0e695318244fc8ee71569fa799c42 |
|---|
| Source note | uspto-grants-2003_07 |
|---|
