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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1359741Generated: October 25, 2026

(R)-Benzyl 2-(pyrrolidine-1-carbonyl)pyrrolidine-1-carboxylate → (R)-Pyrrolidin-2-YL-pyrrolidin-1-YL-methanone

https://huagongshe.com/reaction/1359741

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(R)-Benzyl 2-(pyrrolidine-1-carbonyl)pyrrolidine-1-carboxylateHCID 667614—
CatalystPalladiumHCID 23938—
SolventMethanolHCID 887—
Product(R)-Pyrrolidin-2-YL-pyrrolidin-1-YL-methanoneHCID 10034997—

Reaction Steps

(R)-2-(pyrrolidine-1-carbonyl)-pyrrolidine-1-carboxylic acid benzyl ester was hydrogenated using Pd/C in methanol at rt for 20 hours to give pyrrolidin-1-yl-(R)-pyrrolidin-2-yl-methanone.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06599902B2
Source datasetuspto-grants-2003_07
ORD IDord-8ce7a5ee3fe64a599e26134685ec6fe1
Source noteuspto-grants-2003_07