(S)-(+)-1-(2-Pyrrolidinylmethyl)pyrrolidine → HCID 59077521, compound

HRID 1359791Notes

Reaction equation

HRID 1359791 reaction equation
O=C1CCC(=O)N1O[C:9]([C:11]1[C:15]([CH3:16])=[C:14](/[CH:17]=[C:18]2\[C:19](=[O:39])[NH:20][C:21]3[C:26]\2=[CH:25][C:24]([S:27]([CH2:30][C:31]2[CH:36]=[C:35]([Cl:37])[CH:34]=[CH:33][C:32]=2[Cl:38])(=[O:29])=[O:28])=[CH:23][CH:22]=3)[NH:13][C:12]=1[CH3:40])=[O:10].[N:41]1([CH2:46][C@@H:47]2[CH2:51][CH2:50][CH2:49][NH:48]2)[CH2:45][CH2:44][CH2:43][CH2:42]1>>[Cl:38][C:32]1[CH:33]=[CH:34][C:35]([Cl:37])=[CH:36][C:31]=1[CH2:30][S:27]([C:24]1[CH:25]=[C:26]2[C:21](=[CH:22][CH:23]=1)[NH:20][C:19](=[O:39])/[C:18]/2=[CH:17]\[C:14]1[NH:13][C:12]([CH3:40])=[C:11]([C:9]([N:48]2[CH2:49][CH2:50][CH2:51][C@H:47]2[CH2:46][N:41]2[CH2:45][CH2:44][CH2:43][CH2:42]2)=[O:10])[C:15]=1[CH3:16])(=[O:28])=[O:29]

Participants

3

Reactant 2

HCID 853152(S)-(+)-1-(2-Pyrrolidinylmethyl)pyrrolidineHCID 88095587HCID 88095587, compound

Product 1

HCID 59077521HCID 59077521, compound

Procedure

5-[5-(2,5-Dichloro-phenylmethanesulfonyl)-2-oxo-1,2-dihydro-indol-(3Z)-ylidenemethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid 2,5-dioxo-pyrrolidin-1-yl ester (120 mg, 0.2 mmol) was coupled with (S)-2-pyrrolidin-1-ylmethyl-pyrrolidine (31 mg, 0.2 mmol) to give the titled compound.

Sources & evidence

ORD record
ord-66196fa95c6f4450880ff9aba8f5a677
Source dataset
uspto-grants-2003_07
Patent number
US06599902B2

Reaction notes

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