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HRID13598

反应详情

EQUATION

反应方程式

HRID 13598 的结构方程式

REACTANTS

反应物

1
结构：COC(=O)[C@@H]1Cc2cc([N+](=O)[O-])c(O)cc2CN1C(=O)OC(C)C
HCID66922926

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)[C@@H]1Cc2cc(N)c(O)cc2CN1C(=O)OC(C)C
HCID66923063

未命名化合物

收率 98.8%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：[Pd]
催化剂HCID23938

Palladium

Pd

结构：CO
溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

(S)-7-Hydroxy-6-nitro-3,4-dihydro-1H-isoquinoline-2,3-dicarboxylic acid 2-isopropyl ester 3-methyl ester (2.0 g) was dissolved in MeOH and 200 mg Pd/C added. The flask was evacuated and placed under balloon pressure of hydrogen. The reaction stirred at r.t. for 1.5 h and was filtered over a plug of celite. The celite plug was washed with EtOAc and DCM. The filtrates were combined and evaporated to provide (S)-6-amino-7-hydroxy-3,4-dihydro-1H-isoquinoline-2,3-dicarboxylic acid 2-isopropyl ester 3-methyl ester (1.8 g). LC-MS (m/z) 310.

WORKUP

后处理

  1. customThe flask was evacuated
  2. filtrationwas filtered over a plug of celite
  3. washThe celite plug was washed with EtOAc and DCM
  4. customevaporated