5-(2,6-Dichloro-phenylmethanesulfonyl)-1,3-dihydro-indol-2-one → HCID 59077515, compound

HRID 1359801Notes

Reaction equation

HRID 1359801 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[CH2:9][S:10]([C:13]1[CH:14]=[C:15]2[C:19](=[CH:20][CH:21]=1)[NH:18][C:17](=[O:22])[CH2:16]2)(=[O:12])=[O:11].[CH:23]1([N:26]2[CH2:31][CH2:30][N:29]([CH2:32][C:33]3[C:34]([CH3:41])=[C:35]([CH:39]=O)[NH:36][C:37]=3[CH3:38])[CH2:28][CH2:27]2)[CH2:25][CH2:24]1>>[CH:23]1([N:26]2[CH2:27][CH2:28][N:29]([CH2:32][C:33]3[C:34]([CH3:41])=[C:35](/[CH:39]=[C:16]4\[C:17](=[O:22])[NH:18][C:19]5[C:15]\4=[CH:14][C:13]([S:10]([CH2:9][C:3]4[C:2]([Cl:1])=[CH:7][CH:6]=[CH:5][C:4]=4[Cl:8])(=[O:12])=[O:11])=[CH:21][CH:20]=5)[NH:36][C:37]=3[CH3:38])[CH2:30][CH2:31]2)[CH2:24][CH2:25]1

Participants

3

Reactant 2

HCID 181797685-(2,6-Dichloro-phenylmethanesulfonyl)-1,3-dihydro-indol-2-oneHCID 18179910HCID 18179910, compound

Product 1

HCID 59077515HCID 59077515, compound

Procedure

5-(2,6-Dichloro-phenylmethanesulfonyl)-1,3-dihydro-indol-2-one (178 mg) was condensed with 4-(4-cyclopropyl-piperazin-1-ylmethyl)-3,5-dimethyl-1H-pyrrole-2-carbaldehyde (125 mg) to give the titled compound.

Sources & evidence

ORD record
ord-26abb63a5ff04d49a81dc4920b888fdb
Source dataset
uspto-grants-2003_07
Patent number
US06599902B2

Reaction notes

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