HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 69997310, compound → (2S,3S)-3-hydroxy-pyrrolidine-2-carboxylic acid cyclopropylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 69997310 | HCID 69997310 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | (2S,3S)-3-hydroxy-pyrrolidine-2-carboxylic acid cyclopropylamide | HCID 69998139 | 99.3% |
Reaction Steps
A solution of (2S,3S)-2-cyclopropylcarbamoyl-3-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester (5.6 g) in 30% of TFA in DCM (50 mL) was stirred at rt for 2 hours. The reaction was concentrated to give 3.5 g of (2S,3S)-3-hydroxy-pyrrolidine-2-carboxylic acid cyclopropylamide as a TFA salt.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06599902B2 |
| Source dataset | uspto-grants-2003_07 |
| ORD ID | ord-8716aea6608b44878e8327663f1126dc |
| Source note | uspto-grants-2003_07 |