HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → (2S,4R)-4-hydroxy-pyrrolidine-2-carboxylic acid cyclopropylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | HCID 69996954 | HCID 69996954 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (2S,4R)-4-hydroxy-pyrrolidine-2-carboxylic acid cyclopropylamide | HCID 28943488 | — |
Reaction Steps
A mixture of (2S,4R)-2-cyclopropylcarbamoyl-4-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester (1.1 g) and TFA (20 mL) in DCM (30 mL) was stirred at rt for 2 hours. The reaction was concentrated to give (2S,4R)-4-hydroxy-pyrrolidine-2-carboxylic acid cyclopropylamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06599902B2 |
| Source dataset | uspto-grants-2003_07 |
| ORD ID | ord-1d7ad7a594814640826d97f95af06b1b |
| Source note | uspto-grants-2003_07 |