1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 59077637, compound

Participants

Reaction Steps

A mixture of {5-[5-(2,6-dichloro-phenylmethanesulfonyl)-2-oxo-1,2-dihydro-indol-(3Z)-ylidenemethyl]-2,4-dimethyl-1H-pyrrol-3-yl}-acetic acid (200 mg, 0.38 mmol), HOBt (52 mg), EDAC (130 mg), cyclopropyl-(R)-1-piperidin-3-ylmethyl-amine (103 mg) and TEA (7 drops) in DMF (2 mL) was stirred at rt for overnight. The reaction was concentrated and purified on a silica gel column to give 89 mg of the titled compound.

Provenance & Evidence