Hydrochloric Acid → HCID 45088410, compound

Participants

Reaction Steps

To a solution of (R)-pyrrolidine-2-carboxylic acid cyclopropyl-methyl-amide (540 mg, 3.21 mmol) in THF (5 mL) at 0° C. was added borane (6.4 mL, 2 eq., 1 M in THF) dropwise. The mixture was allowed to warm up to rt then heated to reflux for 24 hours. The cooled reaction was acidified with HCl and heated at 75° C. for 10 mins. The mixture was concentrated, basified with 2N NaOH and extracted with 10% methanol in DCM. The combined DCM was dried and concentrated to give cyclopropyl-methyl-(R)-1-pyrrolidin-2-ylmethyl-amine.

Provenance & Evidence