2-(3-Fluoropiperidin-1-yl)ethan-1-amine → HCID 59077468, compound

HRID 1359867Notes

Reaction equation

HRID 1359867 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[CH2:9][S:10]([C:13]1[CH:14]=[C:15]2[C:19](=[CH:20][CH:21]=1)[NH:18][C:17](=[O:22])/[C:16]/2=[CH:23]\[C:24]1[NH:28][C:27]([CH3:29])=[C:26]([C:30](O)=[O:31])[C:25]=1[CH3:33])(=[O:12])=[O:11].[F:34][CH:35]1[CH2:40][CH2:39][CH2:38][N:37]([CH2:41][CH2:42][NH2:43])[CH2:36]1>>[F:34][CH:35]1[CH2:40][CH2:39][CH2:38][N:37]([CH2:41][CH2:42][NH:43][C:30]([C:26]2[C:25]([CH3:33])=[C:24](/[CH:23]=[C:16]3\[C:17](=[O:22])[NH:18][C:19]4[C:15]\3=[CH:14][C:13]([S:10]([CH2:9][C:3]3[C:2]([Cl:1])=[CH:7][CH:6]=[CH:5][C:4]=3[Cl:8])(=[O:11])=[O:12])=[CH:21][CH:20]=4)[NH:28][C:27]=2[CH3:29])=[O:31])[CH2:36]1

Participants

3

Reactant 2

HCID 181797472-(3-Fluoropiperidin-1-yl)ethan-1-amineHCID 590775075-[5-(2,6-dichloro-phenylmethanesulfonyl)-2-oxo-1,2-dihydro-indol-(3Z)-ylidenemethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

Product 1

HCID 59077468HCID 59077468, compound

Procedure

5-[5-(2,6-Dichloro-phenylmethanesulfonyl)-2-oxo-1,2-dihydro-indol-(3Z)-ylidenemethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid was coupled with 2-(3-fluoro-piperidin-1-yl)-ethylamine to give the titled compound.

Sources & evidence

ORD record
ord-ebabad6046c04b97afd459563dc9789b
Source dataset
uspto-grants-2003_07
Patent number
US06599902B2

Reaction notes

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